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Improving the spectrophotometric determination of the alkylating activity of anticancer agents: a new insight into the mechanism of the NBP method.

par Dierickx, Karen M E;Journé, Fabrice ;Gerbaux, Pascal;Morandini, R;Kauffmann, Jean-Michel ;Ghanem, Ghanem Elias
Référence Talanta, 77, 4, page (1370-1375)
Publication Publié, 2009-02

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Titre:	Improving the spectrophotometric determination of the alkylating activity of anticancer agents: a new insight into the mechanism of the NBP method.
Auteur:	Dierickx, Karen M E; Journé, Fabrice; Gerbaux, Pascal; Morandini, R; Kauffmann, Jean-Michel; Ghanem, Ghanem Elias
Informations sur la publication:	Talanta, 77, 4, page (1370-1375)
Statut de publication:	Publié, 2009-02
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Bischloroethyl alkylating agents
	Epstein reaction
	Modified NBP method
	Stability chromophore
MeSH keywords:	Acetates -- chemistry
	Alkylating Agents -- pharmacology
	Alkylation
	Antineoplastic Agents -- pharmacology
	Chloroform -- analysis
	Humans
	Hydrogen-Ion Concentration
	Hydrolysis
	Models, Chemical
	Reproducibility of Results
	Sensitivity and Specificity
	Spectrophotometry -- methods
	Temperature
	Time Factors
	Water -- analysis
Note générale:	Journal Article
Langue:	Anglais
Identificateurs:	urn:issn:0039-9140
	info:doi/10.1016/j.talanta.2008.09.015
	info:pii/S0039-9140(08)00678-4
	info:scp/57249089045
	info:pmid/19084651