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A novel transport and delivery mechanism underpins the effectiveness of prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF) in a human melanoma xenograft nude-mouse model.

par Dierickx, Karen M E;Morandini, R;Nguyen, Thi hien ;Sales, Francois;Kauffmann, Jean-Michel ;Ghanem, Ghanem Elias
Référence Pigment Cell & Melanoma Research, 21, 4, page (439-450)
Publication Publié, 2008-08

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Titre:	A novel transport and delivery mechanism underpins the effectiveness of prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF) in a human melanoma xenograft nude-mouse model.
Auteur:	Dierickx, Karen M E; Morandini, R; Nguyen, Thi hien; Sales, Francois; Kauffmann, Jean-Michel; Ghanem, Ghanem Elias
Informations sur la publication:	Pigment Cell & Melanoma Research, 21, 4, page (439-450)
Statut de publication:	Publié, 2008-08
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Alkylating agents
	Drug targeting and delivery
	Human melanoma-bearing nude mice
	Melphalan
	PSF
	Tumor-associated proteases
MeSH keywords:	Animals
	Antineoplastic Agents -- administration & dosage
	Antineoplastic Agents -- pharmacokinetics
	Antineoplastic Agents -- pharmacology
	Dipeptides -- administration & dosage
	Dipeptides -- pharmacokinetics
	Dipeptides -- pharmacology
	Drug Delivery Systems -- methods
	Drug Stability
	Humans
	Melanoma -- drug therapy
	Melanoma -- pathology
	Melphalan -- pharmacology
	Melphalan -- therapeutic use
	Mice
	Mice, Nude
	Models, Biological
	Treatment Outcome
	Tumor Cells, Cultured
	Xenograft Model Antitumor Assays
	p-Fluorophenylalanine -- administration & dosage
	p-Fluorophenylalanine -- analogs & derivatives
	p-Fluorophenylalanine -- pharmacokinetics
	p-Fluorophenylalanine -- pharmacology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:1755-1471
	info:doi/10.1111/j.1755-148X.2008.00471.x
	info:pii/PCR471
	info:scp/47249108628
	info:pmid/18627526