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Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.

par Sánchez Más, Jesús;Olivares Sánchez, Concepción;Ghanem, Ghanem Elias ;Haycock, John W.;Lozano Teruel, José Antonio;García-Borrón, J C;Jimenez-Cervantes Frigo, Célia
Référence European journal of biochemistry / FEBS, 269, 24, page (6133-6141)
Publication Publié, 2002-12

Article révisé par les pairs

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Titre:	Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.
Auteur:	Sánchez Más, Jesús; Olivares Sánchez, Concepción; Ghanem, Ghanem Elias; Haycock, John W.; Lozano Teruel, José Antonio; García-Borrón, J C; Jimenez-Cervantes Frigo, Célia
Informations sur la publication:	European journal of biochemistry / FEBS, 269, 24, page (6133-6141)
Statut de publication:	Publié, 2002-12
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Functional coupling
	Loss-of-function mutations
	Melanocortin 1 receptor
	melanoma
	Structure-function relationships
MeSH keywords:	Alleles
	Amino Acid Sequence
	Animals
	Arginine -- chemistry
	Blotting, Western
	CHO Cells
	Cell Line
	Cell Membrane -- metabolism
	Cells, Cultured
	Cloning, Molecular
	Cricetinae
	Cyclic AMP -- metabolism
	DNA, Complementary -- metabolism
	Dose-Response Relationship, Drug
	Heterozygote
	Homozygote
	Humans
	Leucine -- chemistry
	Melanoma -- genetics
	Melanoma -- metabolism
	Mice
	Molecular Sequence Data
	Mutagenesis, Site-Directed
	Mutation
	Protein Conformation
	Protein Structure, Tertiary
	Receptors, Corticotropin -- genetics
	Receptors, Corticotropin -- physiology
	Receptors, Melanocortin
	Sequence Homology, Amino Acid
	Structure-Activity Relationship
	Tumor Cells, Cultured
	Ultraviolet Rays
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0014-2956
	info:doi/10.1046/j.1432-1033.2002.03329.x
	info:pii/3329
	info:scp/0036451652
	info:pmid/12473109