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Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.

par Costagliola, Sabine ;Bonomi, M;Morgenthaler, N G;Van Durme, Joost ;Panneels, Valérie;Refetoff, Samuel ;Vassart, Gilbert
Référence Molecular endocrinology, 18, 12, page (3020-3034)
Publication Publié, 2004-12

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Titre:	Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.
Auteur:	Costagliola, Sabine; Bonomi, M; Morgenthaler, N G; Van Durme, Joost; Panneels, Valérie; Refetoff, Samuel; Vassart, Gilbert
Informations sur la publication:	Molecular endocrinology, 18, 12, page (3020-3034)
Statut de publication:	Publié, 2004-12
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Amino Acid Sequence
	Animals
	Antibodies, Monoclonal -- immunology
	Antibodies, Monoclonal -- pharmacology
	Autoantibodies -- immunology
	Autoantibodies -- pharmacology
	Binding Sites, Antibody -- genetics
	Binding Sites, Antibody -- immunology
	Cyclic AMP -- metabolism
	Disease Models, Animal
	Epitope Mapping
	Female
	Graves Disease -- immunology
	Humans
	Hybridomas
	Hyperthyroidism -- chemically induced
	Hyperthyroidism -- immunology
	Hyperthyroidism -- pathology
	Immunoglobulin Fab Fragments -- immunology
	Immunoglobulins, Thyroid-Stimulating
	Mice
	Molecular Sequence Data
	Receptors, Thyrotropin -- agonists
	Receptors, Thyrotropin -- chemistry
	Receptors, Thyrotropin -- immunology
	Thyroid Gland -- drug effects
	Thyroid Gland -- pathology
	Thyroiditis, Autoimmune -- immunology
	Thyrotropin -- blood
	Thyrotropin -- physiology
	Thyroxine -- blood
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0888-8809
	info:doi/10.1210/me.2004-0231
	info:pii/me.2004-0231
	info:scp/9644295678
	info:pmid/15319453