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Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.

par Sebille, Sophie;Gall, David ;de Tullio, Pascal;Florence, Xavier ;Lebrun, Philippe ;Pirotte, Bernard
Référence Journal of medicinal chemistry, 49, 15, page (4690-4697)
Publication Publié, 2006-07

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Titre:	Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
Auteur:	Sebille, Sophie; Gall, David; de Tullio, Pascal; Florence, Xavier; Lebrun, Philippe; Pirotte, Bernard
Informations sur la publication:	Journal of medicinal chemistry, 49, 15, page (4690-4697)
Statut de publication:	Publié, 2006-07
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenosine Triphosphate -- physiology
	Animals
	Aorta, Thoracic -- drug effects
	Aorta, Thoracic -- physiology
	Benzopyrans -- chemical synthesis
	Benzopyrans -- chemistry
	Benzopyrans -- pharmacology
	Cromakalim -- chemistry
	Insulin -- secretion
	Insulin-Secreting Cells -- drug effects
	Insulin-Secreting Cells -- physiology
	Insulin-Secreting Cells -- secretion
	Ion Channel Gating -- drug effects
	Muscle Contraction
	Muscle, Smooth, Vascular -- drug effects
	Muscle, Smooth, Vascular -- physiology
	Patch-Clamp Techniques
	Phenylurea Compounds -- chemical synthesis
	Phenylurea Compounds -- chemistry
	Phenylurea Compounds -- pharmacology
	Potassium Channels -- drug effects
	Rats
	Rats, Wistar
	Stereoisomerism
	Structure-Activity Relationship
Note générale:	In Vitro
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm060161z
	info:scp/33746708715
	info:pmid/16854075