Titre:
  • Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
Auteur:Sebille, Sophie; Gall, David; de Tullio, Pascal; Florence, Xavier; Lebrun, Philippe; Pirotte, Bernard
Informations sur la publication:Journal of medicinal chemistry, 49, 15, page (4690-4697)
Statut de publication:Publié, 2006-07
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Adenosine Triphosphate -- physiology
Animals
Aorta, Thoracic -- drug effects
Aorta, Thoracic -- physiology
Benzopyrans -- chemical synthesis
Benzopyrans -- chemistry
Benzopyrans -- pharmacology
Cromakalim -- chemistry
Insulin -- secretion
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- physiology
Insulin-Secreting Cells -- secretion
Ion Channel Gating -- drug effects
Muscle Contraction
Muscle, Smooth, Vascular -- drug effects
Muscle, Smooth, Vascular -- physiology
Patch-Clamp Techniques
Phenylurea Compounds -- chemical synthesis
Phenylurea Compounds -- chemistry
Phenylurea Compounds -- pharmacology
Potassium Channels -- drug effects
Rats
Rats, Wistar
Stereoisomerism
Structure-Activity Relationship
Note générale:In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0022-2623
info:doi/10.1021/jm060161z
info:scp/33746708715
info:pmid/16854075