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Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.

par Philippart, Pierre;Harper, Luke H.;Chaboteaux, Carole ;Decaestecker, Christine ;Bronckart, Yves ;Gordover, L;Lesueur-Ginot, L;Malonne, Hugues ;Lavergne, O;Bigg, D C;Mendes Da Costa, Pierre ;Kiss, Robert
Référence Clinical cancer research, 6, 4, page (1557-1562)
Publication Publié, 2000-04

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Titre:	Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.
Auteur:	Philippart, Pierre; Harper, Luke H.; Chaboteaux, Carole; Decaestecker, Christine; Bronckart, Yves; Gordover, L; Lesueur-Ginot, L; Malonne, Hugues; Lavergne, O; Bigg, D C; Mendes Da Costa, Pierre; Kiss, Robert
Informations sur la publication:	Clinical cancer research, 6, 4, page (1557-1562)
Statut de publication:	Publié, 2000-04
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Antineoplastic Agents -- pharmacology
	Biopsy
	Camptothecin -- analogs & derivatives
	Camptothecin -- pharmacology
	Cell Division -- drug effects
	Colon -- drug effects
	Colon -- pathology
	Colonic Neoplasms -- drug therapy
	Colonic Neoplasms -- pathology
	Culture Techniques
	DNA Topoisomerases, Type I -- antagonists & inhibitors
	DNA Topoisomerases, Type I -- metabolism
	Dose-Response Relationship, Drug
	Doxorubicin -- pharmacology
	Enzyme Inhibitors -- pharmacology
	Etoposide -- pharmacology
	Humans
	Thymidine -- metabolism
	Topotecan -- pharmacology
	Tritium -- diagnostic use
	Tumor Cells, Cultured
Note générale:	Comparative Study
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:1078-0432
	info:pmid/10778989