Titre:
  • A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.
Auteur:Claeysen, Sylvie; Govaerts, Cédric; Lefort, Anne; Van Sande, Jacqueline; Costagliola, Sabine; Pardo, Leonardo; Vassart, Gilbert
Informations sur la publication:FEBS letters, 517, 1-3, page (195-200)
Statut de publication:Publié, 2002-04
Sujet CREF:Sciences bio-médicales et agricoles
Biochimie
Biologie
Biologie cellulaire
Biologie moléculaire
Biophysique
Sciences biomédicales
Sciences de la matière vivante
Biochimie
Biologie
Biologie cellulaire
Biologie moléculaire
Biophysique
Sciences biomédicales
Sciences de la matière vivante
Mots-clés:Activation mechanism
Constitutive activity
G protein-coupled receptor
Natural mutation
Thyroid-stimulating hormone receptor
MeSH keywords:Animals
Asparagine -- genetics
Asparagine -- metabolism
Binding Sites
COS Cells
Cercopithecus aethiops
Cyclic AMP -- metabolism
Membrane Glycoproteins -- chemistry
Membrane Glycoproteins -- genetics
Membrane Glycoproteins -- metabolism
Mutagenesis, Site-Directed
Protein Conformation
Receptors, Thyrotropin -- chemistry
Receptors, Thyrotropin -- genetics
Receptors, Thyrotropin -- metabolism
Thyrotropin -- metabolism
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0014-5793
info:doi/10.1016/S0014-5793(02)02620-0
info:pii/S0014579302026200
info:scp/0037165664
info:pmid/12062436