• Citer

Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour.

par Driessens, Grégory ;Harsan, L;Robaye, Bernard ;Waroquier, Dominique ;Browaeys, Patrick ;Giannakopoulos, Xenofon;Velu, Thierry ;Bruyns, C
Référence British Journal of Cancer, 89, 4, page (727-729)
Publication Publié, 2003-08

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

Apoptosis induction and micronuclei formation were compared following cytotoxic treatments in two rat glioma differing in p53 integrity. In vitro, micronuclei emergence but not apoptosis was linked to the p53 mutated status. In vivo, micronuclei assays were more sensitive to evaluate DNA damage induced by chemotherapy in a p53-mutated solid tumour.