Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin.

Langlois, N; Rojas-Rousseau, A; Gaspard, C; Werner, G. H.; Darro, Francis; Kiss, Robert

doi:doi/10.1021/jm010937q

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Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin.

par Langlois, N ;Rojas-Rousseau, A ;Gaspard, C ;Werner, G. H.;Darro, Francis ;Kiss, Robert

Référence Journal of medicinal chemistry, 44, 22, page (3754-3757)
Publication Publié, 2001-10

Article révisé par les pairs

Résumé :

A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its water-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against several tumor cell lines. The new pyrrolo[2,1-c][1,4]benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-sensitive cell lines tested.

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