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Lysine 195 and aspartate 196 in the first extracellular loop of the VPAC1 receptor are essential for high affinity binding of agonists but not of antagonists.

par Langer, Ingrid ;Vertongen, Pascale ;Perret, Jason ;Waelbroeck, Magali ;Robberecht, Patrick
Référence Neuropharmacology, 44, 1, page (125-131)
Publication Publié, 2003-01

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Titre:	Lysine 195 and aspartate 196 in the first extracellular loop of the VPAC1 receptor are essential for high affinity binding of agonists but not of antagonists.
Auteur:	Langer, Ingrid; Vertongen, Pascale; Perret, Jason; Waelbroeck, Magali; Robberecht, Patrick
Informations sur la publication:	Neuropharmacology, 44, 1, page (125-131)
Statut de publication:	Publié, 2003-01
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenylate Cyclase -- metabolism
	Amino Acid Substitution
	Animals
	Aspartic Acid -- genetics
	Binding, Competitive
	CHO Cells
	Cell Membrane -- metabolism
	Cricetinae
	Humans
	Ligands
	Lysine -- genetics
	Mutagenesis, Site-Directed
	Protein Structure, Secondary
	Radioligand Assay
	Receptors, Vasoactive Intestinal Peptide -- agonists
	Receptors, Vasoactive Intestinal Peptide -- antagonists & inhibitors
	Receptors, Vasoactive Intestinal Peptide -- metabolism
	Receptors, Vasoactive Intestinal Polypeptide, Type I
	Structure-Activity Relationship
	Vasoactive Intestinal Peptide -- metabolism
Note générale:	Comparative Study
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0028-3908
	info:pii/S0028390802002332
	info:pmid/12559130