Titre:
  • Ac His1 [D-Phe2, K15, R16, L27] VIP (3-7)/GRF (8-27)--a VPAC1 receptor antagonist--is an inverse agonist on two constitutively active truncated VPAC1 receptors.
Auteur:Vertongen, Pascale; Langlet, Christelle; Langer, Ingrid; Gaspard, Nathalie; Robberecht, Patrick
Informations sur la publication:Peptides, 25, 11, page (1943-1949)
Statut de publication:Publié, 2004-11
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Chinese hamster ovary cells
CHO
concentration of agonist required for half maximal response
Constitutive activity
EC
EC50
extracellular loops
GRF
Inverse agonism
Truncated recombinant receptors
VPAC1 receptor
MeSH keywords:Adenylate Cyclase -- metabolism
Amino Acid Sequence
Animals
Binding, Competitive
CHO Cells
Clone Cells
Cricetinae
Cricetulus
Humans
Inhibitory Concentration 50
Iodine Radioisotopes -- diagnostic use
Ligands
Molecular Sequence Data
Peptides, Cyclic -- pharmacology
Protein Conformation
Receptors, Vasoactive Intestinal Peptide -- chemistry
Receptors, Vasoactive Intestinal Peptide -- metabolism
Receptors, Vasoactive Intestinal Polypeptide, Type I
Recombinant Proteins -- chemistry
Recombinant Proteins -- metabolism
Transfection
Vasoactive Intestinal Peptide -- chemical synthesis
Vasoactive Intestinal Peptide -- chemistry
Vasoactive Intestinal Peptide -- isolation & purification
Vasoactive Intestinal Peptide -- pharmacology
Note générale:Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0196-9781
info:doi/10.1016/j.peptides.2004.06.001
info:pii/S0196978104002530
info:scp/6344280474
info:pmid/15501526