par Zhang, H;Xu, Yong;Markadieu, Nicolas 
;Beauwens, Renaud ;Erneux, Christophe ;Prestwich, Glenn D
Référence Bioorganic & medicinal chemistry letters, 18, 2, page (762-766)
Publication Publié, 2008-01
;Beauwens, Renaud ;Erneux, Christophe ;Prestwich, Glenn DRéférence Bioorganic & medicinal chemistry letters, 18, 2, page (762-766)
Publication Publié, 2008-01
Article révisé par les pairs
| Résumé : | Metabolically-stabilized analogs of PtdIns(3,4,5)P(3) have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P(3). Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT(3)-mimicked insulin in activating sodium transport in A6 cells. |
