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Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi.

par Mathieu, Anne ;Remmelink, Myriam ;D'Haene, Nicky ;Penant, Stanislas;Gaussin, Jean-François ;Van Ginckel, Rob;Darro, Francis;Kiss, Robert ;Salmon, Isabelle
Référence Cancer, 101, 8, page (1908-1918)
Publication Publié, 2004-10

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Titre:	Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi.
Auteur:	Mathieu, Anne; Remmelink, Myriam; D'Haene, Nicky; Penant, Stanislas; Gaussin, Jean-François; Van Ginckel, Rob; Darro, Francis; Kiss, Robert; Salmon, Isabelle
Informations sur la publication:	Cancer, 101, 8, page (1908-1918)
Statut de publication:	Publié, 2004-10
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Chemoresistance
	Cyclooxygenase-2
	Glutathione-S-transferase
	Lung-related resistance protein
	Nonsmall cell lung carcinoma
	NS-398
	Ornithine decarboxylase
	Orthotopic model
	Prostaglandin E synthetase
MeSH keywords:	Animals
	Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
	Brain Neoplasms -- drug therapy
	Brain Neoplasms -- metabolism
	Brain Neoplasms -- secondary
	Camptothecin -- administration & dosage
	Camptothecin -- analogs & derivatives
	Carcinoma, Non-Small-Cell Lung -- drug therapy
	Carcinoma, Non-Small-Cell Lung -- metabolism
	Carcinoma, Non-Small-Cell Lung -- pathology
	Cyclooxygenase 2
	Disease Models, Animal
	Drug Resistance, Neoplasm
	Female
	Glutathione S-Transferase pi
	Glutathione Transferase -- metabolism
	Humans
	Intramolecular Oxidoreductases -- metabolism
	Isoenzymes -- metabolism
	Liver Neoplasms -- drug therapy
	Liver Neoplasms -- metabolism
	Liver Neoplasms -- secondary
	Lung Neoplasms -- drug therapy
	Lung Neoplasms -- metabolism
	Lung Neoplasms -- pathology
	Membrane Proteins
	Mice
	Mice, Nude
	Neoplasm Proteins -- metabolism
	Organoplatinum Compounds -- administration & dosage
	Ornithine Decarboxylase -- metabolism
	Paclitaxel -- administration & dosage
	Prostaglandin-Endoperoxide Synthases -- metabolism
	Survival Rate
	Transplantation, Heterologous
	Tumor Markers, Biological -- metabolism
	Vault Ribonucleoprotein Particles -- metabolism
Note générale:	Comparative Study
	Journal Article
	Research Support, Non-U.S. Gov't
	FLWIN
Langue:	Anglais
Identificateurs:	urn:issn:0008-543X
	info:doi/10.1002/cncr.20571
	info:scp/4944242194
	info:pmid/15386340