• Citer

Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.

par Van Quaquebeke, Eric ;Simon, Gentiane;André, Aurélie;Dewelle, Janique;El Yazidi, Mohamed ;Bruyneel, Frederic;Tuti, Jérôme;Nacoulma, Odile;Guissou, Pierre;Decaestecker, Christine ;Braekman, Jean Claude ;Kiss, Robert ;Darro, Francis
Référence Journal of medicinal chemistry, 48, 3, page (849-856)
Publication Publié, 2005-02

Article révisé par les pairs

• Détails
• Contenu

Titre:	Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Auteur:	Van Quaquebeke, Eric; Simon, Gentiane; André, Aurélie; Dewelle, Janique; El Yazidi, Mohamed; Bruyneel, Frederic; Tuti, Jérôme; Nacoulma, Odile; Guissou, Pierre; Decaestecker, Christine; Braekman, Jean Claude; Kiss, Robert; Darro, Francis
Informations sur la publication:	Journal of medicinal chemistry, 48, 3, page (849-856)
Statut de publication:	Publié, 2005-02
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Antineoplastic Agents -- chemical synthesis
	Antineoplastic Agents -- isolation & purification
	Antineoplastic Agents -- pharmacology
	Calotropis -- chemistry
	Camptothecin -- analogs & derivatives
	Camptothecin -- pharmacology
	Cardenolides -- chemical synthesis
	Cardenolides -- isolation & purification
	Cardenolides -- pharmacology
	Cell Line, Tumor
	Cell Proliferation -- drug effects
	Cerebral Cortex -- chemistry
	Drug Resistance, Multiple
	Drug Resistance, Neoplasm
	Drug Screening Assays, Antitumor
	Etoposide -- pharmacology
	Humans
	Magnetic Resonance Spectroscopy
	Maximum Tolerated Dose
	Mice
	Organoplatinum Compounds -- pharmacology
	Paclitaxel -- pharmacology
	Sodium-Potassium-Exchanging ATPase -- chemistry
	Structure-Activity Relationship
	Swine
	Thiazoles -- chemical synthesis
	Thiazoles -- isolation & purification
	Thiazoles -- pharmacology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm049405a
	info:scp/20044369153
	info:pmid/15689169