• Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1).
Auteur:Depoortere, Fabienne; Pirson, Isabelle; Bartek, Jiri; Dumont, Jacques Emile; Roger, Pierre P.
Informations sur la publication:Molecular biology of the cell, 11, 3, page (1061-1076)
Statut de publication:Publié, 2000-03
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Animals
Biological Transport
CDC2-CDC28 Kinases
Cell Cycle -- physiology
Cell Cycle Proteins
Cell Division
Cells, Cultured
Cyclic AMP -- physiology
Cyclin D3
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases -- metabolism
Cyclins -- metabolism
DNA-Binding Proteins -- metabolism
Epithelial Cells -- cytology
Gene Expression
Microtubule-Associated Proteins -- metabolism
Mitogens -- pharmacology
Protein Binding
Protein-Serine-Threonine Kinases -- metabolism
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-myc -- biosynthesis
Retinoblastoma Protein -- metabolism
Smad2 Protein
Smad3 Protein
Thyroid Gland -- cytology
Thyrotropin -- metabolism
Trans-Activators -- metabolism
Transforming Growth Factor beta -- physiology
Tumor Suppressor Proteins
Note générale:Journal Article
Research Support, Non-U.S. Gov't