par Carlier, Yves 
Référence Revista da sociedade Brasileira de Medicina Tropical, 38 Suppl 2, page (105-107)
Publication Publié, 2005
Référence Revista da sociedade Brasileira de Medicina Tropical, 38 Suppl 2, page (105-107)
Publication Publié, 2005
Article révisé par les pairs
| Résumé : | This paper synthesizes the results obtained from multidisciplinary studies of Bolivian cases of congenital infection with T. cruzi. Congenital infection and congenital Chagas disease do not result from transmission of a particular strain of parasite, but from an equilibrium between complex phenomena, such as a weak maternal type 1 adaptative immune response associated with high maternal parasitemia, an invasion of placental chorion and umbilical cord by parasites, in front of a fetal T. cruzi-specific immune response characterized by an activation of cytotoxic CD8 T cells producing IFN-gamma and able to limit parasite multiplication and morbi-mortality of congenital Chagas disease. |
