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7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.

par Azéma, Joëlle;Guidetti, Brigitte;Dewelle, Janique;Le Calve, Benjamin ;Mijatovic, Tatjana ;Korolyov, Alexander;Vaysse, Julie;Malet-Martino, Myriam;Martino, Robert;Kiss, Robert
Référence Bioorganic & medicinal chemistry, 17, 15, page (5396-5407)
Publication Publié, 2009-08

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Titre:	7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.
Auteur:	Azéma, Joëlle; Guidetti, Brigitte; Dewelle, Janique; Le Calve, Benjamin; Mijatovic, Tatjana; Korolyov, Alexander; Vaysse, Julie; Malet-Martino, Myriam; Martino, Robert; Kiss, Robert
Informations sur la publication:	Bioorganic & medicinal chemistry, 17, 15, page (5396-5407)
Statut de publication:	Publié, 2009-08
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Cancer cell lines
	Fluoroquinolones
	In vitro biological evaluation
	Lipophilic ciprofloxacin derivatives
MeSH keywords:	Animals
	Antineoplastic Agents -- chemistry
	Antineoplastic Agents -- pharmacology
	Antineoplastic Agents -- toxicity
	Cell Line, Tumor
	Cell Proliferation -- drug effects
	Ciprofloxacin -- analogs & derivatives
	Ciprofloxacin -- chemical synthesis
	Ciprofloxacin -- pharmacology
	Ciprofloxacin -- toxicity
	Humans
	Maximum Tolerated Dose
	Mice
	Neoplasms -- drug therapy
	Piperazines -- chemical synthesis
	Piperazines -- chemistry
	Piperazines -- pharmacology
	Piperazines -- toxicity
Note générale:	Journal Article
Langue:	Anglais
Identificateurs:	urn:issn:0968-0896
	info:doi/10.1016/j.bmc.2009.06.053
	info:pii/S0968-0896(09)00618-X
	info:scp/67651125000
	info:pmid/19595598