par Saussez, Sven 
;Kiss, Robert
Référence Cellular and molecular life sciences, 63, 6, page (686-697)
Publication Publié, 2006-03
;Kiss, Robert Référence Cellular and molecular life sciences, 63, 6, page (686-697)
Publication Publié, 2006-03
Article révisé par les pairs
| Résumé : | Galectins are a family of animal lectins with an affinity for beta-galactosides. They are differentially expressed by various tissues and appear to be functionally multivalent, exerting a wide range of biological activities both during development and in adult tissue. Galectin-7, a member of this family, contributes to different events associated with the differentiation and development of pluristratified epithelia. It is also associated with epithelial cell migration, which plays a crucial role in the re-epithelialization process of corneal or epidermal wounds. In addition, recent evidence indicates that galectin-7, designated as the product of the p53-induced gene 1 (PIG1), is a regulator of apoptosis through JNK activation and mitochondrial cytochrome c release. Defects in apoptosis constitute one of the major hallmarks of human cancers, and galectin-7 can act as either a positive or a negative regulatory factor in tumour development, depending on the histological type of the tumour. |
