• Citer

The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin.

par Springael, Jean-Yves ;De Poorter, Cédric ;Deupi, Xavier;Van Durme, Joost ;Pardo, Leonardo;Parmentier, Marc
Référence Cellular signalling, 19, 7, page (1446-1456)
Publication Publié, 2007-07

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Titre:	The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin.
Auteur:	Springael, Jean-Yves; De Poorter, Cédric; Deupi, Xavier; Van Durme, Joost; Pardo, Leonardo; Parmentier, Marc
Informations sur la publication:	Cellular signalling, 19, 7, page (1446-1456)
Statut de publication:	Publié, 2007-07
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Activation
	CCR5
	Constitutive activity
MeSH keywords:	Amino Acid Sequence
	Animals
	CHO Cells
	Cattle
	Chemokine CCL4
	Computational Biology
	Cricetinae
	Cricetulus
	Down-Regulation -- drug effects
	Down-Regulation -- genetics
	Endocytosis -- drug effects
	Enzyme Activation -- drug effects
	Kinetics
	Ligands
	Macrophage Inflammatory Proteins -- pharmacology
	Mitogen-Activated Protein Kinases -- metabolism
	Molecular Sequence Data
	Mutant Proteins -- genetics
	Mutant Proteins -- metabolism
	Protein Structure, Quaternary
	Protein Structure, Secondary
	Protein Structure, Tertiary
	Receptors, CCR5 -- chemistry
	Receptors, CCR5 -- metabolism
	Rhodopsin -- chemistry
	Rhodopsin -- metabolism
	Structure-Activity Relationship
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0898-6568
	info:doi/10.1016/j.cellsig.2007.01.022
	info:pii/S0898-6568(07)00036-8
	info:scp/34249332756
	info:pmid/17320349