Titre:
  • Highly potent HIV inhibition: engineering a key anti-HIV structure from PSC-RANTES into MIP-1 beta/CCL4.
Auteur:Gaertner, Hubert; Lebeau, Olivier; Borlat, Irène; Cerini, Fabrice; Dufour, Brigitte; Kuenzi, Gabriel; Melotti, Astrid; Fish, Richard J; Offord, Robin; Springael, Jean-Yves; Parmentier, Marc; Hartley, Oliver
Informations sur la publication:Protein engineering, design & selection, 21, 2, page (65-72)
Statut de publication:Publié, 2008-02
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:CCR5
HIV coreceptor
MIP-1β CCL4
Pharmacophore grafting
PSC-RANTES
MeSH keywords:Amino Acid Sequence
Anti-HIV Agents -- chemical synthesis
Cells, Cultured
Chemokine CCL4 -- genetics
Chemokine CCL4 -- therapeutic use
Chemokine CCL5 -- genetics
Chemokine CCL5 -- therapeutic use
Drug Design
HIV -- drug effects
Humans
Molecular Sequence Data
Structure-Activity Relationship
Note générale:Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:1741-0126
info:doi/10.1093/protein/gzm079
info:pii/gzm079
info:scp/39749128458
info:pmid/18178567