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Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.

par Lepesheva, Galina I;Park, Hee-Won;Hargrove, Tatiana Y;Vanhollebeke, Benoît ;Wawrzak, Zdzislaw;Harp, Joel M;Sundaramoorthy, Munirathinam;Nes, W David;Pays, Etienne ;Chaudhuri, Minu;Villalta, Fernando;Waterman, Michael R
Référence The Journal of biological chemistry, 285, 3, page (1773-1780)
Publication Publié, 2010-01

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Titre:	Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
Auteur:	Lepesheva, Galina I; Park, Hee-Won; Hargrove, Tatiana Y; Vanhollebeke, Benoît; Wawrzak, Zdzislaw; Harp, Joel M; Sundaramoorthy, Munirathinam; Nes, W David; Pays, Etienne; Chaudhuri, Minu; Villalta, Fernando; Waterman, Michael R
Informations sur la publication:	The Journal of biological chemistry, 285, 3, page (1773-1780)
Statut de publication:	Publié, 2010-01
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Amino Acid Sequence
	Benzamides -- chemistry
	Benzamides -- metabolism
	Benzamides -- pharmacology
	Benzamides -- therapeutic use
	Biocatalysis
	Crystallography, X-Ray
	Cytochrome P-450 Enzyme System -- antagonists & inhibitors
	Cytochrome P-450 Enzyme System -- chemistry
	Cytochrome P-450 Enzyme System -- metabolism
	Drug Design
	Enzyme Inhibitors -- chemistry
	Enzyme Inhibitors -- metabolism
	Enzyme Inhibitors -- pharmacology
	Enzyme Inhibitors -- therapeutic use
	Humans
	Ligands
	Microsomes -- enzymology
	Models, Molecular
	Protein Conformation
	Sterols -- biosynthesis
	Substrate Specificity
	Trypanocidal Agents -- chemistry
	Trypanocidal Agents -- metabolism
	Trypanocidal Agents -- pharmacology
	Trypanocidal Agents -- therapeutic use
	Trypanosoma brucei brucei -- drug effects
	Trypanosoma brucei brucei -- enzymology
	Trypanosomiasis, African -- drug therapy
Note générale:	Journal Article
	Research Support, N.I.H., Extramural
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0021-9258
	info:doi/10.1074/jbc.M109.067470
	info:pii/M109.067470
	info:scp/76249100348
	info:pmid/19923211