Titre:
  • Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.
Auteur:Paternot, Sabine; Roger, Pierre P.
Informations sur la publication:Cancer research, 69, 11, page (4577-4581)
Statut de publication:Publié, 2009-06
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Benzamides -- administration & dosage
Benzamides -- pharmacology
Cell Line, Tumor
Cell Proliferation -- drug effects
Cyclin-Dependent Kinase 4 -- metabolism
DNA Replication -- drug effects
Drug Combinations
Drug Evaluation, Preclinical
Glioblastoma -- metabolism
Glioblastoma -- pathology
Humans
MAP Kinase Kinase 1 -- antagonists & inhibitors
MAP Kinase Kinase 2 -- antagonists & inhibitors
Phosphorylation -- drug effects
Protein Kinase Inhibitors -- administration & dosage
Protein Kinase Inhibitors -- pharmacology
Protein Kinases -- metabolism
Proteins -- antagonists & inhibitors
Proteins -- metabolism
Retinoblastoma Protein -- metabolism
Sirolimus -- administration & dosage
Sirolimus -- pharmacology
Transcription Factors -- antagonists & inhibitors
Tumor Cells, Cultured
Note générale:Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0008-5472
info:doi/10.1158/0008-5472.CAN-08-3260
info:pii/0008-5472.CAN-08-3260
info:scp/66349086978
info:pmid/19458076