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Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.

par Paternot, Sabine ;Roger, Pierre P.
Référence Cancer research, 69, 11, page (4577-4581)
Publication Publié, 2009-06

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Titre:	Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.
Auteur:	Paternot, Sabine; Roger, Pierre P.
Informations sur la publication:	Cancer research, 69, 11, page (4577-4581)
Statut de publication:	Publié, 2009-06
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Benzamides -- administration & dosage
	Benzamides -- pharmacology
	Cell Line, Tumor
	Cell Proliferation -- drug effects
	Cyclin-Dependent Kinase 4 -- metabolism
	DNA Replication -- drug effects
	Drug Combinations
	Drug Evaluation, Preclinical
	Glioblastoma -- metabolism
	Glioblastoma -- pathology
	Humans
	MAP Kinase Kinase 1 -- antagonists & inhibitors
	MAP Kinase Kinase 2 -- antagonists & inhibitors
	Phosphorylation -- drug effects
	Protein Kinase Inhibitors -- administration & dosage
	Protein Kinase Inhibitors -- pharmacology
	Protein Kinases -- metabolism
	Proteins -- antagonists & inhibitors
	Proteins -- metabolism
	Retinoblastoma Protein -- metabolism
	Sirolimus -- administration & dosage
	Sirolimus -- pharmacology
	Transcription Factors -- antagonists & inhibitors
	Tumor Cells, Cultured
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0008-5472
	info:doi/10.1158/0008-5472.CAN-08-3260
	info:pii/0008-5472.CAN-08-3260
	info:scp/66349086978
	info:pmid/19458076