par Blairy, Sylvie;Massat, Isabelle 
;Staner, Luc ;Le Bon, Olivier ;Van Gestel, Sofie;Van Broeckhoven, Christine;Hilger, Christiane;Hentges, François;Souery, Daniel ;Mendlewicz, Julien
Référence American journal of medical genetics, 96, 3, page (360-364)
Publication Publié, 2000-06
;Staner, Luc ;Le Bon, Olivier ;Van Gestel, Sofie;Van Broeckhoven, Christine;Hilger, Christiane;Hentges, François;Souery, Daniel ;Mendlewicz, Julien Référence American journal of medical genetics, 96, 3, page (360-364)
Publication Publié, 2000-06
Article révisé par les pairs
| Résumé : | The purpose [corrected] of this study was to investigate the relationship between bipolar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5-HTR2a (chromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bipolar patients and 89 normal subjects completed the TPQ questionnaire and were genotyped for 5-HT2a. Bipolar patients scored higher than normal subjects on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect. |
