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Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

par Cnop, Miriam ;Ladrière, Laurence ;Hekerman, Paul ;Ortis, Fernanda ;Dogusan, Zeynep ;Flamez, Daisy ;Boyce, M.;Yuan, J.;Eizirik, Decio L. ;Cardozo, Alessandra K
Référence The Journal of biological chemistry, 282, 6, page (3989-3997)
Publication Publié, 2007

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Titre:	Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
Auteur:	Cnop, Miriam; Ladrière, Laurence; Hekerman, Paul; Ortis, Fernanda; Dogusan, Zeynep; Flamez, Daisy; Boyce, M.; Yuan, J.; Eizirik, Decio L.; Cardozo, Alessandra K
Informations sur la publication:	The Journal of biological chemistry, 282, 6, page (3989-3997)
Statut de publication:	Publié, 2007
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Apoptosis -- drug effects
	Apoptosis -- physiology
	Cells, Cultured
	Cinnamates -- pharmacology
	Endoplasmic Reticulum -- drug effects
	Endoplasmic Reticulum -- metabolism
	Endoplasmic Reticulum -- pathology
	Eukaryotic Initiation Factor-2 -- antagonists & inhibitors
	Eukaryotic Initiation Factor-2 -- metabolism
	Fatty Acids, Nonesterified -- physiology
	Insulin-Secreting Cells -- drug effects
	Insulin-Secreting Cells -- metabolism
	Insulin-Secreting Cells -- pathology
	Male
	Oxidative Stress -- drug effects
	Oxidative Stress -- physiology
	Phosphorylation -- drug effects
	Rats
	Rats, Wistar
	Thiourea -- analogs & derivatives
	Thiourea -- pharmacology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0021-9258
	info:doi/10.1074/jbc.M607627200
	info:pii/M607627200
	info:scp/33947510911
	info:pmid/17158450