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The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts.

par Dumont, Patrick;Ingrassia, Laurent ;Rouzeau, Sébastien;Ribaucour, Fabrice;Thomas, Stéphanie;Roland, Isabelle ;Darro, Francis;Lefranc, Florence ;Kiss, Robert
Référence Neoplasia (New York, N.Y.), 9, 9, page (766-776)
Publication Publié, 2007-09

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Titre:	The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts.
Auteur:	Dumont, Patrick; Ingrassia, Laurent; Rouzeau, Sébastien; Ribaucour, Fabrice; Thomas, Stéphanie; Roland, Isabelle; Darro, Francis; Lefranc, Florence; Kiss, Robert
Informations sur la publication:	Neoplasia (New York, N.Y.), 9, 9, page (766-776)
Statut de publication:	Publié, 2007-09
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Amaryllidaceae Alkaloids -- isolation & purification
	Amaryllidaceae Alkaloids -- pharmacology
	Antigens, CD95 -- drug effects
	Antigens, CD95 -- physiology
	Antineoplastic Agents, Phytogenic -- isolation & purification
	Antineoplastic Agents, Phytogenic -- pharmacology
	Apoptosis -- drug effects
	Apoptosis -- physiology
	BH3 Interacting Domain Death Agonist Protein -- physiology
	Breast Neoplasms -- metabolism
	Breast Neoplasms -- pathology
	Carcinoma -- metabolism
	Carcinoma -- pathology
	Caspases -- physiology
	Cytochromes c -- analysis
	DNA Fragmentation
	Drug Resistance, Neoplasm
	Enzyme Activation -- drug effects
	Female
	Fibroblasts -- drug effects
	Humans
	Male
	Mitochondria -- enzymology
	Mitochondria -- physiology
	Narcissus -- chemistry
	Neoplasm Proteins -- drug effects
	Neoplasm Proteins -- physiology
	Phenanthridines -- isolation & purification
	Phenanthridines -- pharmacology
	Prostatic Neoplasms -- metabolism
	Prostatic Neoplasms -- pathology
	Receptors, Tumor Necrosis Factor -- physiology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:1476-5586
	info:pmid/17898872
	PMC1993861