• The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts.
Auteur:Dumont, Patrick; Ingrassia, Laurent; Rouzeau, Sébastien; Ribaucour, Fabrice; Thomas, Stéphanie; Roland, Isabelle; Darro, Francis; Lefranc, Florence; Kiss, Robert
Informations sur la publication:Neoplasia (New York, N.Y.), 9, 9, page (766-776)
Statut de publication:Publié, 2007-09
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Amaryllidaceae Alkaloids -- isolation & purification
Amaryllidaceae Alkaloids -- pharmacology
Antigens, CD95 -- drug effects
Antigens, CD95 -- physiology
Antineoplastic Agents, Phytogenic -- isolation & purification
Antineoplastic Agents, Phytogenic -- pharmacology
Apoptosis -- drug effects
Apoptosis -- physiology
BH3 Interacting Domain Death Agonist Protein -- physiology
Breast Neoplasms -- metabolism
Breast Neoplasms -- pathology
Carcinoma -- metabolism
Carcinoma -- pathology
Caspases -- physiology
Cytochromes c -- analysis
DNA Fragmentation
Drug Resistance, Neoplasm
Enzyme Activation -- drug effects
Fibroblasts -- drug effects
Mitochondria -- enzymology
Mitochondria -- physiology
Narcissus -- chemistry
Neoplasm Proteins -- drug effects
Neoplasm Proteins -- physiology
Phenanthridines -- isolation & purification
Phenanthridines -- pharmacology
Prostatic Neoplasms -- metabolism
Prostatic Neoplasms -- pathology
Receptors, Tumor Necrosis Factor -- physiology
Note générale:Journal Article
Research Support, Non-U.S. Gov't