• Citer

2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.

par Van Quaquebeke, Eric ;Mahieu, Tina ;Dumont, Patrick;Dewelle, Janique;Ribaucour, Fabrice;Simon, Gentiane;Sauvage, Sébastien ;Gaussin, Jean-François ;Tuti, Jérôme;El Yazidi, Mohamed ;Van Vynckt, Frank;Mijatovic, Tatjana ;Lefranc, Florence ;Darro, Francis;Kiss, Robert
Référence Journal of medicinal chemistry, 50, 17, page (4122-4134)
Publication Publié, 2007-08

Article révisé par les pairs

• Détails
• Contenu

Titre:	2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.
Auteur:	Van Quaquebeke, Eric; Mahieu, Tina; Dumont, Patrick; Dewelle, Janique; Ribaucour, Fabrice; Simon, Gentiane; Sauvage, Sébastien; Gaussin, Jean-François; Tuti, Jérôme; El Yazidi, Mohamed; Van Vynckt, Frank; Mijatovic, Tatjana; Lefranc, Florence; Darro, Francis; Kiss, Robert
Informations sur la publication:	Journal of medicinal chemistry, 50, 17, page (4122-4134)
Statut de publication:	Publié, 2007-08
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Acetamides -- chemical synthesis
	Acetamides -- pharmacology
	Acetamides -- toxicity
	Animals
	Antineoplastic Agents -- chemical synthesis
	Antineoplastic Agents -- pharmacology
	Antineoplastic Agents -- toxicity
	Apoptosis
	Autophagy
	Camptothecin -- analogs & derivatives
	Camptothecin -- pharmacology
	Cell Aging
	Cell Line, Tumor
	DNA Topoisomerases, Type I -- antagonists & inhibitors
	Deoxycytidine -- analogs & derivatives
	Deoxycytidine -- pharmacology
	Drug Screening Assays, Antitumor
	Erythrocyte Count
	Female
	Humans
	Imides -- pharmacology
	Imides -- toxicity
	Isoquinolines -- chemical synthesis
	Isoquinolines -- pharmacology
	Isoquinolines -- toxicity
	Leukocyte Count
	Maximum Tolerated Dose
	Mice
	Naphthalimides -- chemical synthesis
	Naphthalimides -- pharmacology
	Naphthalimides -- toxicity
	Neoplasm Transplantation
	Platelet Count
	Structure-Activity Relationship
	Urea -- analogs & derivatives
	Urea -- chemical synthesis
	Urea -- pharmacology
	Urea -- toxicity
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm070315q
	info:scp/34548138904
	info:pmid/17658777