par Surquin, Murielle ;Buonocore, Sofia ;Le Moine, Alain ;Flamand, Véronique ;Goldman, Michel ;Abramowicz, Daniel
Référence Néphrologie & thérapeutique, 1, 3, page (161-166)
Publication Publié, 2005-07
Référence Néphrologie & thérapeutique, 1, 3, page (161-166)
Publication Publié, 2005-07
Article révisé par les pairs
Résumé : | Because rejection of allografts is primarily caused by T and B lymphocyte responses to allogeneic histocompatibility molecules, the role of innate immunity in organ transplant rejection is often overlooked. However, the very first damages to vascularized organ allografts are caused by ischemia-reperfusion, an inflammatory reaction involving activation of vascular endothelial cells and release of neutrophil chemoattractants. Herein, we review experimental observations suggesting that the early neutrophil influx in organ transplants favors T cell-mediated rejection. |