par Aksoy, Ezra 
;Goldman, Michel ;Willems, Fabienne
Référence International journal of biochemistry & cell biology, 36, 2, page (183-188)
Publication Publié, 2004-02
;Goldman, Michel ;Willems, Fabienne Référence International journal of biochemistry & cell biology, 36, 2, page (183-188)
Publication Publié, 2004-02
Article révisé par les pairs
| Résumé : | Recent advances in understanding the molecular basis for mammalian host immune responses to microbial invasion suggest that the first line of defense against microbes is the recognition of pathogen-associated molecular patterns by a set of germline-encoded receptors: the Toll-like receptors (TLRs). TLRs have been identified as being part of a large family of pathogen-recognition receptors that play a decisive role in the induction of both innate and adaptive immunity. Indeed, activation of T lymphocytes depends on their interaction with dendritic cells previously stimulated by TLR agonists such as bacterial lipopolysaccharide (LPS), a TLR-4 ligand. A novel PKC epsilon (epsilon) was recently found to be a critical component of TLR-4 signaling pathway and thereby to play a key role in macrophage and dendritic cell (DC) activation in response to LPS. Thus, controlling the kinase activity of PKC epsilon might represent an efficient strategy to prevent or treat certain inflammatory disorders of microbial origin. |
