Article révisé par les pairs
Titre:
  • Rottlerin inhibits human T cell responses.
Auteur:Springael, Cécile; Thomas, Séverine; Rahmouni, Souad; Vandamme, Arnaud; Goldman, Michel; Willems, Fabienne; Vosters, Olivier
Informations sur la publication:Biochemical pharmacology, 73, 4, page (515-525)
Statut de publication:Publié, 2007-02
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Human T cells
Protein kinase C θ
Rottlerin
TCR/CD28 stimulation
MeSH keywords:Acetophenones -- pharmacology
Antigens, CD -- metabolism
Antigens, CD28 -- genetics
Antigens, CD28 -- metabolism
Antigens, CD8 -- metabolism
Antigens, Differentiation, T-Lymphocyte -- metabolism
Benzopyrans -- pharmacology
Blotting, Western
CD4-Positive T-Lymphocytes -- cytology
CD4-Positive T-Lymphocytes -- drug effects
CD4-Positive T-Lymphocytes -- metabolism
CD8-Positive T-Lymphocytes -- cytology
CD8-Positive T-Lymphocytes -- drug effects
CD8-Positive T-Lymphocytes -- metabolism
Calcium -- metabolism
Cell Proliferation -- drug effects
Cytokines -- genetics
Cytokines -- metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors -- pharmacology
Flow Cytometry
Humans
Interleukin-2 -- antagonists & inhibitors
Interleukin-2 -- immunology
Interleukin-2 Receptor alpha Subunit -- genetics
Interleukin-2 Receptor alpha Subunit -- metabolism
Intracellular Signaling Peptides and Proteins -- genetics
Intracellular Signaling Peptides and Proteins -- metabolism
Propidium -- metabolism
Protein Kinase C-delta -- antagonists & inhibitors
Protein Tyrosine Phosphatases -- genetics
Protein Tyrosine Phosphatases -- metabolism
Protein Tyrosine Phosphatases, Non-Receptor
RNA, Messenger -- genetics
RNA, Messenger -- metabolism
Reverse Transcriptase Polymerase Chain Reaction
Sirolimus -- pharmacology
Th1 Cells -- drug effects
Th1 Cells -- metabolism
Th2 Cells -- drug effects
Th2 Cells -- metabolism
Thymidine -- metabolism
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0006-2952
info:doi/10.1016/j.bcp.2006.10.034
info:pii/S0006-2952(06)00695-2
info:scp/33845926805
info:pmid/17141738