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Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the 3' untranslated region.

par Paludan, S R;Ellermann-Eriksen, S;Kruys, Véronique ;Mogensen, S C
Référence The Journal of immunology, 167, 4, page (2202-2208)
Publication Publié, 2001-08

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Titre:	Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the 3' untranslated region.
Auteur:	Paludan, S R; Ellermann-Eriksen, S; Kruys, Véronique; Mogensen, S C
Informations sur la publication:	The Journal of immunology, 167, 4, page (2202-2208)
Statut de publication:	Publié, 2001-08
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	3' Untranslated Regions -- physiology
	Activating Transcription Factor 2
	Animals
	Binding Sites -- genetics
	Binding Sites -- immunology
	Cells, Cultured
	Cyclic AMP Response Element-Binding Protein -- genetics
	Cyclic AMP Response Element-Binding Protein -- metabolism
	Cyclic AMP Response Element-Binding Protein -- physiology
	DNA-Binding Proteins -- biosynthesis
	DNA-Binding Proteins -- genetics
	Dinucleotide Repeats -- physiology
	Female
	Herpesvirus 2, Human -- immunology
	I-kappa B Proteins
	Interferon-gamma -- pharmacology
	Macrophage Activation -- genetics
	Macrophage Activation -- immunology
	Macrophages, Peritoneal -- immunology
	Macrophages, Peritoneal -- metabolism
	Macrophages, Peritoneal -- virology
	Mice
	Mice, Inbred C57BL
	Mutation
	NF-kappa B -- antagonists & inhibitors
	NF-kappa B -- genetics
	NF-kappa B -- physiology
	Promoter Regions, Genetic -- immunology
	Proto-Oncogene Proteins c-jun -- physiology
	RNA, Messenger -- antagonists & inhibitors
	RNA, Messenger -- biosynthesis
	Transcription Factors -- genetics
	Transcription Factors -- metabolism
	Transcription Factors -- physiology
	Transcriptional Activation -- physiology
	Transfection
	Tumor Necrosis Factor-alpha -- antagonists & inhibitors
	Tumor Necrosis Factor-alpha -- biosynthesis
	Tumor Necrosis Factor-alpha -- genetics
	Tumor Necrosis Factor-alpha -- secretion
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-1767
	info:pmid/11490006