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Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.

par Aksoy, Ezra ;Vanden Berghe, Wim;Detienne, Sophie ;Amraoui, Zoulikha ;Fitzgerald, Kathrine A;Haegeman, Guy;Goldman, Michel ;Willems, Fabienne
Référence European Journal of Immunology, 35, 7, page (2200-2209)
Publication Publié, 2005-07

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Titre:	Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.
Auteur:	Aksoy, Ezra; Vanden Berghe, Wim; Detienne, Sophie; Amraoui, Zoulikha; Fitzgerald, Kathrine A; Haegeman, Guy; Goldman, Michel; Willems, Fabienne
Informations sur la publication:	European Journal of Immunology, 35, 7, page (2200-2209)
Statut de publication:	Publié, 2005-07
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Dendritic cell
	Interferon
	NF-κB
	PI3 kinase
	TRIF
MeSH keywords:	1-Phosphatidylinositol 3-Kinase -- antagonists & inhibitors
	1-Phosphatidylinositol 3-Kinase -- metabolism
	Adaptor Proteins, Vesicular Transport -- physiology
	Androstadienes -- pharmacology
	Chromones -- pharmacology
	DNA-Binding Proteins -- metabolism
	Dendritic Cells -- immunology
	Dendritic Cells -- metabolism
	Down-Regulation
	Enzyme Inhibitors -- pharmacology
	Humans
	Interferon Regulatory Factor-3
	Interferon-beta -- biosynthesis
	Lipopolysaccharides -- immunology
	Membrane Glycoproteins -- metabolism
	Morpholines -- pharmacology
	NF-kappa B -- metabolism
	Receptors, Cell Surface -- metabolism
	Toll-Like Receptor 3
	Toll-Like Receptor 4
	Toll-Like Receptors
	Transcription Factors -- metabolism
	Transcription, Genetic -- physiology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	FLWIN
Langue:	Anglais
Identificateurs:	urn:issn:0014-2980
	info:doi/10.1002/eji.200425801
	info:scp/22544445221
	info:pmid/15940673