Titre:
  • Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.
Auteur:Aksoy, Ezra; Vanden Berghe, Wim; Detienne, Sophie; Amraoui, Zoulikha; Fitzgerald, Kathrine A; Haegeman, Guy; Goldman, Michel; Willems, Fabienne
Informations sur la publication:European Journal of Immunology, 35, 7, page (2200-2209)
Statut de publication:Publié, 2005-07
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Dendritic cell
Interferon
NF-κB
PI3 kinase
TRIF
MeSH keywords:1-Phosphatidylinositol 3-Kinase -- antagonists & inhibitors
1-Phosphatidylinositol 3-Kinase -- metabolism
Adaptor Proteins, Vesicular Transport -- physiology
Androstadienes -- pharmacology
Chromones -- pharmacology
DNA-Binding Proteins -- metabolism
Dendritic Cells -- immunology
Dendritic Cells -- metabolism
Down-Regulation
Enzyme Inhibitors -- pharmacology
Humans
Interferon Regulatory Factor-3
Interferon-beta -- biosynthesis
Lipopolysaccharides -- immunology
Membrane Glycoproteins -- metabolism
Morpholines -- pharmacology
NF-kappa B -- metabolism
Receptors, Cell Surface -- metabolism
Toll-Like Receptor 3
Toll-Like Receptor 4
Toll-Like Receptors
Transcription Factors -- metabolism
Transcription, Genetic -- physiology
Note générale:Journal Article
Research Support, Non-U.S. Gov't
FLWIN
Langue:Anglais
Identificateurs:urn:issn:0014-2980
info:doi/10.1002/eji.200425801
info:scp/22544445221
info:pmid/15940673