• Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response.
Auteur:Muraille, Eric; De Trez, Carl; Brait, Maryse; De Baetselier, Patrick; Leo, Oberdan; Carlier, Yves
Informations sur la publication:The Journal of immunology, 170, 8, page (4237-4241)
Statut de publication:Publié, 2003-04
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Adaptor Proteins, Signal Transducing
Antigens, Differentiation -- genetics
Antigens, Differentiation -- physiology
Cell Differentiation -- genetics
Cell Differentiation -- immunology
Crosses, Genetic
Genetic Predisposition to Disease
Immunity, Innate -- genetics
Injections, Intraperitoneal
Interferon-gamma -- biosynthesis
Interleukin-12 -- administration & dosage
Interleukin-4 -- biosynthesis
Leishmania major -- immunology
Leishmaniasis, Cutaneous -- genetics
Leishmaniasis, Cutaneous -- immunology
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Myeloid Differentiation Factor 88
Receptors, Immunologic -- deficiency
Receptors, Immunologic -- genetics
Receptors, Immunologic -- physiology
Signal Transduction -- genetics
Signal Transduction -- immunology
Th2 Cells -- cytology
Th2 Cells -- immunology
Th2 Cells -- metabolism
Note générale:Journal Article
Research Support, Non-U.S. Gov't