par Schaeffer, Laurent;de Kerchove d'Exaerde, Alban 
;Changeux, J.-P.
Référence Neuron, 31, 1, page (15-22)
Publication Publié, 2001-07
;Changeux, J.-P.Référence Neuron, 31, 1, page (15-22)
Publication Publié, 2001-07
Article révisé par les pairs
| Résumé : | Concomitant with innervation, genes coding for components of the neuromuscular junction become exclusively expressed in subsynaptic nuclei. A six-base pair element, the N box, can confer synapse-specific transcription to the acetylcholine nicotinic receptor delta and epsilon subunit, utrophin, and acetylcholine esterase genes. N box-dependent synaptic expression is stimulated by the nerve-derived signal agrin and the trophic factor neuregulin, which triggers the MAPK and JNK signaling pathways, to ultimately allow activation by the N box binding Ets transcription factor GABP. |
