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The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.

par Catty, P.;de Kerchove d'Exaerde, Alban ;Goffeau, A
Référence FEBS letters, 409, 3, page (325-332)
Publication Publié, 1997-06

Article révisé par les pairs

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Résumé :

A total of sixteen open reading frames encoding for P-type ATPases have been identified in the complete genome sequence of Saccharomyces cerevisiae. Phylogenetic analysis distinguishes 6 distinct families. Topology predictions, identification of aminoacid sequence motifs and phenotype analysis of the available mutants suggest that these families correspond to ATPases transporting either H+ (2 members), Ca2+ (2 members), Na+ (3 members), heavy metals (2 members), possibly aminophospholipids (5 members including 4 new ones) or unknown substrates (2 new members). It is proposed that the latter family which has homologs in Tetrahymena thermophila, Plasmodium falciparum and Caenorhabditis elegans constitutes a new group called P4-ATPases with characteristic topology and aminoacid signatures.