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D2R striatopallidal neurons inhibit both locomotor and drug reward processes.

par Durieux, Pierre ;Bearzatto, Bertrand ;Guiducci, Stefania;Buch, Thorsten;Waisman, Ari;Zoli, M;Schiffmann, Serge N. ;de Kerchove d'Exaerde, Alban
Référence Nature neuroscience, 12, 4, page (393-395)
Publication Publié, 2009-04

Article révisé par les pairs

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Résumé :

The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.