Titre:
  • Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Auteur:Andrade Da Cunha, Daniel; Hekerman, Paul; Ladrière, Laurence; Bazarra-Castro, A.; Ortis, Fernanda; Wakeham, Marion; Moore, Fabrice; Rasschaert, Joanne; Cardozo, Alessandra K; Bellomo, Elisa; Overbergh, Lutgart; Mathieu, Chantal; Lupi, R.; Hai, Tsonwin; Herchuelz, André; Marchetti, Piero; Rutter, Guy A; Eizirik, Decio L.; Cnop, Miriam
Informations sur la publication:Journal of cell science, 121, Pt 14, page (2308-2318)
Statut de publication:Publié, 2008
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Apoptosis
Endoplasmic reticulum stress
Fatty acid
Islet
Lipotoxicity
Oleate
Palmitate
Pancreatic β-cell
Type 2 diabetes
MeSH keywords:Activating Transcription Factor 3 -- metabolism
Activating Transcription Factor 6 -- metabolism
Animals
Apoptosis -- drug effects
Calcium -- metabolism
Endoplasmic Reticulum -- drug effects
Endoplasmic Reticulum -- enzymology
Endoplasmic Reticulum -- pathology
Fatty Acids, Nonesterified -- metabolism
Fatty Acids, Nonesterified -- toxicity
Glucose -- toxicity
Humans
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- enzymology
Insulin-Secreting Cells -- pathology
JNK Mitogen-Activated Protein Kinases -- metabolism
Male
Membrane Proteins -- metabolism
Mice
Middle Aged
Protein-Serine-Threonine Kinases -- metabolism
Rats
Rats, Wistar
Signal Transduction -- drug effects
Transcription Factor CHOP -- metabolism
eIF-2 Kinase -- metabolism
Note générale:Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0021-9533
info:doi/10.1242/jcs.026062
info:pii/jcs.026062
info:scp/49649084031
info:pmid/18559892