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Early induction of apoptosis in B-chronic lymphocytic leukaemia cells by hydroxychloroquine: activation of caspase-3 and no protection by survival factors

par Lagneaux, Laurence ;Delforge, Alain ;Carlier, Stefaan;Massy, M;Bernier, Michel ;Bron, Dominique
Référence British journal of haematology, 112, 2, page (344-352)
Publication Publié, 2001-02

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Titre:	Early induction of apoptosis in B-chronic lymphocytic leukaemia cells by hydroxychloroquine: activation of caspase-3 and no protection by survival factors
Auteur:	Lagneaux, Laurence; Delforge, Alain; Carlier, Stefaan; Massy, M; Bernier, Michel; Bron, Dominique
Informations sur la publication:	British journal of haematology, 112, 2, page (344-352)
Statut de publication:	Publié, 2001-02
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Aged
	Aged, 80 and over
	Antirheumatic Agents -- therapeutic use
	Apoptosis
	Caspase 3
	Caspases -- metabolism
	Dose-Response Relationship, Drug
	Enzyme Activation
	Female
	Humans
	Hydroxychloroquine -- therapeutic use
	Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
	Leukemia, Lymphocytic, Chronic, B-Cell -- pathology
	Male
	Membrane Potentials
	Middle Aged
	Mitochondria -- metabolism
	Proto-Oncogene Proteins c-bcl-2 -- metabolism
	Tumor Cells, Cultured -- drug effects
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	FLWIN
Langue:	Anglais
Identificateurs:	urn:issn:0007-1048
	info:doi/10.1046/j.1365-2141.2001.02553.x
	info:pii/bjh2553
	info:scp/0035126893
	info:pmid/11167827