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Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.

par Ullmann, Heiko;Meis, Sabine;Hongwiset, Darunee;Marzian, Claudia;Wiese, Michael;Nickel, Peter;Communi, Didier ;Boeynaems, Jean-Marie ;Wolf, Christian;Hausmann, Ralf;Schmalzing, Günther;Kassack, Matthias U
Référence Journal of medicinal chemistry, 48, 22, page (7040-7048)
Publication Publié, 2005-11

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Titre:	Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.
Auteur:	Ullmann, Heiko; Meis, Sabine; Hongwiset, Darunee; Marzian, Claudia; Wiese, Michael; Nickel, Peter; Communi, Didier; Boeynaems, Jean-Marie; Wolf, Christian; Hausmann, Ralf; Schmalzing, Günther; Kassack, Matthias U
Informations sur la publication:	Journal of medicinal chemistry, 48, 22, page (7040-7048)
Statut de publication:	Publié, 2005-11
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Calcium -- metabolism
	Cell Line
	Electrophysiology
	Humans
	Oocytes -- drug effects
	Oocytes -- physiology
	Quantitative Structure-Activity Relationship
	Rats
	Receptors, Purinergic P2 -- antagonists & inhibitors
	Receptors, Purinergic P2 -- genetics
	Receptors, Purinergic P2 -- physiology
	Reverse Transcriptase Polymerase Chain Reaction
	Suramin -- analogs & derivatives
	Suramin -- chemical synthesis
	Suramin -- pharmacology
	Transfection
	Xenopus laevis
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm050301p
	info:scp/27444436716
	info:pmid/16250663