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Tumor necrosis factor-α induces the phosphorylation of 28kDa stress proteins in endothelial cells: Possible role in protection against cytotoxicity?

par Robaye, Bernard ;Hepburn, Anne ;Lecocq, Raymond ;Fiers, Walter;Boeynaems, Jean-Marie ;Dumont, Jacques Emile
Référence Biochemical and biophysical research communications, 163, 1, page (301-308)
Publication Publié, 1989-08

Article révisé par les pairs

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Résumé :

Tumor necrosis factor-alpha has been shown to rapidly increase the phosphorylation of three 28 kDa proteins in bovine aortic endothelial cells but not in L929 cells. Tumor necrosis factor-alpha induces the necrosis of the latter cells but not of the former. Arsenite enhanced the phosphorylation of the same 28kDa proteins as tumor necrosis factor-alpha in the endothelial cells. As stress proteins often play a protective role, we suggest that the phosphorylation of these proteins in endothelial cells may be responsible for the resistance of these cells to tumor necrosis factor-alpha.