P2-purinergic receptors in vascular endothelial cells: from concept to reality.

Boeynaems, Jean-Marie; Pirotton, Sabine; Van Coevorden, Anne; Raspé, Eric; Demolle, Dominique; Erneux, Christophe

doi:doi/10.3109/10799898809048982

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P2-purinergic receptors in vascular endothelial cells: from concept to reality.

par Boeynaems, Jean-Marie

;Pirotton, Sabine

;Van Coevorden, Anne

;Raspé, Eric

;Demolle, Dominique ;Erneux, Christophe

Référence Journal of receptor research, 8, 1-4, page (121-132)
Publication Publié, 1988

Article révisé par les pairs

Résumé :

ATP exerts at least 2 actions on arterial endothelial cells: it stimulates the release of endothelium-derived relaxing factor, a still unidentified vasodilator, and of prostacyclin, a potent inhibitor of platelet aggregation. A study of agonist specificity indicates that these responses are mediated by P2-purinergic receptors. We have now demonstrated that in these cells, the P2-receptors are coupled to a phospholipase C hydrolysing phosphatidylinositol-bisphosphate and that this coupling involves a pertussis toxin-sensitive GTP-binding regulatory protein.

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