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Inositol polyphosphate kinase activity of Arg82/ArgRIII is not required for the regulation of the arginine metabolism in yeast

par Dubois, Evelyne ;Dewaste, Valérie ;Erneux, Christophe ;Messenguy, Francine
Référence FEBS letters, 486, 3, page (300-304)
Publication Publié, 2000-12

Article révisé par les pairs

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Résumé :

Arg82, a nuclear regulator of diverse cellular processes in yeast, is an inositol polyphosphate kinase. Some defects such as the regulation of arginine metabolism observed in an arg82Δ, result from a lack of Mcm1 and Arg80 stability. We show here that neither the kinase activity of Arg82 nor inositol phosphates are required for the control of arginine metabolism. Arg82 mutations keeping kinase active affect the expression of arginine genes, whereas mutations in the kinase domain do not impair this metabolic control. Copyright (C) 2000 Federation of European Biochemical Societies.