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Release of the ammonia effect on three catabolic enzymes by NADP-specific glutamate dehydrogenaseless mutations in Saccharomyces cerevisiae

par Dubois, Evelyne ;Grenson, Marcelle ;Wiame, Jean-Marie
Référence Biochemical and biophysical research communications, 50, 4, page (967-972)
Publication Publié, 1973-02

Article révisé par les pairs

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Résumé :

Mutations which inactivate the NADP-glutamate dehydrogenase (anabolic GDHase) pleiotropically release the ammonia inhibition (NH4+ effect) on a number of distinct catabolic activities. In addition to releasing inhibition on several permeability functions (1), these mutations suppress the NH4+ effect on the synthesis of arginase, urea amidolyase and allantoinase. They do not affect the NH4+ effect on the NAD-glutamate dehydrogenase. Two mechanisms of action of these mutations have to be considered, namely a modification of the process of induction (such as removal of inducer exclusion) and a suppression of nitrogen catabolite repression. © 1973.