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Cerebrospinal fluid circulating tumor DNA profiling in central nervous system metastases from solid tumors: A prospective multicentre translational analysis of the BrainStorm (OncoDistinct-006) study.

par Arecco, Luca ;Rothé, Françoise;Venet, David ;Gombos, Andrea ;Gonçalves, Anthony;De Maio D'Esposito, Eleonora;Barthélémy, Philippe;Vanhaudenarde, Vincent;Clatot, Florian;Holbrechts, Stephane;Duhoux, Francois P;Borcoman, Edith;Cheymol, Claire;Gligorov, Joseph;Denys, Hannelore;Clement, Paul M;Punie, Kevin;Duhem, Caroline;Decoster, Lore;Canon, Jean-Luc;Lefranc, Florence ;Rasschaert, Marika;Kindt, Nadège;Čular, Katarina;Gentile, Gabriella;Paulus, Kristanto;Pop, Elisabeth;Delaroche, Diane ;de Azambuja, Evandro;Awada, Ahmad;Kotecki, Nuria
Référence The journal of liquid biopsy, 14, page (100492)
Publication Publié, 2026-08-01

Article révisé par les pairs

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Résumé :

Central nervous system (CNS) metastases represent a complication in solid tumors and often harbour unique genomic alterations diverging from those in primary tumor tissue or plasma; however, direct sampling of CNS lesions carries procedural risks, limiting its molecular profiling. The main aim of the present analysis was to assess the feasibility of Cerebrospinal Fluid (CSF) ctDNA profiling and to descriptively compare genomic alterations detected in matched tumor tissue, plasma, and CSF samples, including in patients with leptomeningeal metastases (LM).