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Dose-dependent regional synchronicity changes using weighted phase lag index: Towards optimizing vagus nerve stimulation titration process

par Cerda, Paloma Cárcamo;Aqueveque, Pablo;Nonclercq, Antoine ;El Tahry, Riëm;Germany, Enrique
Référence Conference proceedings
Publication Publié, 2025-10-01

Article révisé par les pairs

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Résumé :

Vagus Nerve Stimulation (VNS) is an effective therapy for drug-resistant epilepsy (DRE), but its efficacy varies across individuals. This study uses the weighted Phase Lag Index (wPLI) across multiple frequency bands to examine the dose-dependent regional brain synchronization effect at an individual level. EEG data from four DRE patients (two responders and two non-responders) were analyzed under controlled VNS intensities. Results show that non-responders exhibit an increased synchrony at higher intensity levels, particularly in the beta band and the broadband. Findings highlight individualized neural responses to VNS, underscoring the possibility for personalized stimulation strategies to optimize therapy.Clinical Relevance - Refining the VNS titration process through dose-dependent brain connectivity analysis could accelerate optimization, improving therapeutic outcomes and personalization for drug-resistant epilepsy patients.