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Descriptive study of stromal expression of CD73 in ductal carcinoma in situ of the breast.

par Catteau, Xavier ;Noël, Jean-Christophe;Fallas, Jennifer ;Charry, Manon;Denis, Zoe;De Caluwé, Alex;Stagg, John;Sotiriou, Christos ;Buisseret, Laurence
Référence Discover Oncology, 17, 1
Publication Publié, 2026-04-01

Article révisé par les pairs

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Résumé :

Cancer-associated fibroblasts (CAFs) could act as a source of resistance to anti-tumor immune response. CD73 is an ectoenzyme that promotes tumour immune escape by producing immunosuppressive extracellular adenosine in the tumour microenvironment. In addition, CD73 is an adhesion molecule binding to other cells and extracellular matrix and facilitates cell motility. Nevertheless, CD73 functions in CAFs remain poorly investigated. Furthermore, it has never been studied in the stroma around lesions of ductal carcinoma in situ (DCIS). We performed this study to determine the expression of CD73 in the stroma of DCIS.