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Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca2+ microdomains to initiate T cell activation.

par Winterberg, Kai KJ;Schwentner, Vanessa;Gu, Ming Feng;Möckl, Franziska;Li, Gaoyang;Bauche, Andreas;Etzold, Stefanie;Rosche, Anette;Weiß, Mariella;Thuille, Nikolaus;Förster, Fritz;Woelk, Lena-Marie;Werner, René;Kovacevic, Dejan;Fehse, Boris;Kurelic, Roberta;Nawrocki, Mikolaj;Huber, Samuel;Mittrücker, Hans-Willi;Meier, Chris;Müller, Christa E;Baier, Gottfried;Skålhegg, Bjørn BS;De Deken, Xavier ;Wahl-Schott, Christian;Mair, Thomas;Siebels, Bente;Cugota Canals, Roger;Odoardi, Francesca;Lodygin, Dmitri;Flügel, Alexander;Nikolaev, Viacheslav O;Diercks, Björn Philipp;Guse, Andreas H
Référence Science Signaling, 19, 920, page (eadp4326)
Publication Publié, 2026-01

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Titre:	Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca2+ microdomains to initiate T cell activation.
Auteur:	Winterberg, Kai KJ; Schwentner, Vanessa; Gu, Ming Feng; Möckl, Franziska; Li, Gaoyang; Bauche, Andreas; Etzold, Stefanie; Rosche, Anette; Weiß, Mariella; Thuille, Nikolaus; Förster, Fritz; Woelk, Lena-Marie; Werner, René; Kovacevic, Dejan; Fehse, Boris; Kurelic, Roberta; Nawrocki, Mikolaj; Huber, Samuel; Mittrücker, Hans-Willi; Meier, Chris; Müller, Christa E; Baier, Gottfried; Skålhegg, Bjørn BS; De Deken, Xavier; Wahl-Schott, Christian; Mair, Thomas; Siebels, Bente; Cugota Canals, Roger; Odoardi, Francesca; Lodygin, Dmitri; Flügel, Alexander; Nikolaev, Viacheslav O; Diercks, Björn Philipp; Guse, Andreas H
Informations sur la publication:	Science Signaling, 19, 920, page (eadp4326)
Statut de publication:	Publié, 2026-01
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Lymphocyte Activation -- immunology
	Dual Oxidases -- metabolism -- genetics
	T-Lymphocytes -- immunology -- metabolism -- cytology
	NADP -- analogs & derivatives -- metabolism -- biosynthesis -- immunology
	Humans
	Calcium -- metabolism
	Animals
	Calcium Signaling
	Receptors, Antigen, T-Cell -- metabolism
	Signal Transduction
	Mice
	Membrane Microdomains -- metabolism
	NADPH Oxidases -- metabolism
	Cyclic AMP-Dependent Protein Kinases -- metabolism -- genetics
	Phosphorylation
	Protein Kinase C-theta -- metabolism -- genetics
	Jurkat Cells
Langue:	Anglais
Identificateurs:	urn:issn:1945-0877
	info:doi/10.1126/scisignal.adp4326
	info:pmid/41529097