Article révisé par les pairs
Résumé : Diabetic wounds are a significant clinical challenge due to chronic inflammation, persistent oxidative stress, hyperglycaemic and hypoxic conditions, bacterial infections, and impaired tissue regeneration, all of which delay healing and increase complications. Addressing these multifaceted issues requires innovative therapeutic strategies capable of modulating the diabetic wound microenvironment. Herein, we developed a polyphenol-assisted gold‑platinum (AuPt) core-shell nanozyme with multi-enzyme mimetic activities, including glucose oxidase (GOD), catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and oxidase (OXD)-like functions. Computational insights based on density functional theory (DFT) further supported the Au–Pt synergistic design. By synergistically combining the catalytic properties of Au and Pt, the nanozyme modulate oxidative stress, and reduces inflammation while promoting fibroblast viability and context-dependent antibacterial activity under acidic, ROS-rich conditions relevant to inflamed wound sites. In vivo experiments using a diabetic mouse model revealed that the developed AuPt nanozymes promoted wound healing by improving epidermal regeneration and collagen synthesis while suppressing pro-inflammatory cytokines, including TNF-α and IL-1β. These results highlight the potential of polyphenol-assisted AuPt nanozymes as a robust and multifunctional therapy to address key pathological barriers in diabetic wound healing, providing a foundation for future clinical applications.

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