Article révisé par les pairs
Titre:
  • SHIP2-PLK1 crosstalk promotes sensitivity to dual inhibition in esophageal squamous cell carcinoma.
Auteur:Ramos, Ana Raquel; Bregni, Giacomo; Gillet, Nadia; Ando, Kunie; Bodart, Cyril; Vercauteren Drubbel, Alizée; Descampe, Louison; Moresi, Fabiana; Bisteau, Xavier; Verheye, Quentin; Pirard, Sheleya; Erneux, Christophe; Beck, Benjamin
Informations sur la publication:Molecular cancer, 24, 1, page (280)
Statut de publication:Publié, 2025-11-01
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Esophageal cancer
PI 5-phosphatase
PI3K
PLK1 inhibitors
Phosphoinositide
SHIP2
Squamous cell carcinoma
Synergy
MeSH keywords:Humans
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases -- genetics -- metabolism -- antagonists & inhibitors
Esophageal Squamous Cell Carcinoma -- drug therapy -- metabolism -- genetics -- pathology
Animals
Mice
Esophageal Neoplasms -- drug therapy -- metabolism -- genetics -- pathology
Cell Line, Tumor
Protein Serine-Threonine Kinases -- metabolism -- genetics -- antagonists & inhibitors
Cell Cycle Proteins -- metabolism -- genetics
Polo-Like Kinase 1
Proto-Oncogene Proteins -- metabolism -- genetics
Cell Proliferation -- drug effects
Xenograft Model Antitumor Assays
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic -- drug effects
Signal Transduction -- drug effects
Langue:Anglais
Identificateurs:urn:issn:1476-4598
info:doi/10.1186/s12943-025-02454-z
info:pii/10.1186/s12943-025-02454-z
info:pmid/41188852
PMC12584323

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