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A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

par Huiskamp, Marijn;Moumdjian, Lousin ;Van Asch, Paul;Popescu, Veronica;Schoonheim, Menno Michiel;Steenwijk, Martijn;Vanzeir, Ellen;van Wijmeersch, Bart;Geurts, Jeroen JG;Feys, Peter;Hulst, Hanneke E.
Référence Multiple sclerosis, 26, 12, page (1594-1598)
Publication Publié, 2020-10-01

Article révisé par les pairs

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Résumé :

Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention ( n = 15) and waitlist group ( n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.