Randomised trial of trastuzumab deruxtecan and biology-driven selection of neoadjuvant treatment for HER2-positive breast cancer: a study protocol of ARIADNE.

Matikas, Alexios; Naume, Bjorn; Wildiers, Hans; Sonke, Gabe GS; Dieci, Maria Vittoria; Karakatsanis, Andreas; Andersson, Anne; Barnekow, Elin; Kessler, Luisa Edman; Einbeigi, Zakaria; Killander, Fredrika; Linderholm, Barbro B.K.; Schiza, Aglaia; Valachis, Antonis; Nearchou, Andreas; Engebraaten, Olav; Porojnicu, Alina; Soland, Mari Hiorth; Mannsåker, Bård; Raj, Sunil Xavier; Blix, Egil Støre; Nordstrand, Cecilie Soma; Lambertini, Matteo; Vernieri, Claudio; Punie, Kevin; Sotiriou, Christos; Bergh, Jonas; Villacampa, Guillermo; Zouzos, Athanasios; Hellström, Mats; Hartman, Johan; Foukakis, Theodoros

doi:doi/10.1136/bmjopen-2025-102626

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Article révisé par les pairs

Résumé :

Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugate approved for the treatment of metastatic HER2-positive and HER2-low BC, with greatly improved efficacy compared to T-DM1.

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